Iontophoresis of cyclic AMP

آدنوزین منوفسفات حلقوی ( Cyclic AMP )

Cyclic AMP-induced conformational change of cyclic AMP receptor protein (CRP): intragenic suppressors of cyclic AMP-independent CRP mutations.

We isolated and characterized crp mutations in Escherichia coli that allow cyclic AMP (cAMP) receptor protein to function without cAMP. These mutants defined a region involved in the cAMP-induced allosteric change of cAMP receptor protein that is necessary for activation of the protein. Currently, we have isolated intragenic suppressors of the crp mutations. These crp (Sup) mutants require cAMP...

The cyclic AMP pathway.

Cyclic adenosine 3′,5′-monophosphate (cAMP) was the first second messenger to be identified and plays fundamental roles in cellular responses to many hormones and neurotransmitters (Sutherland and Rall 1958). The intracellular levels of cAMP are regulated by the balance between the activities of two enzymes (see Fig. 1): adenylyl cyclase (AC) and cyclic nucleotide phosphodiesterase (PDE). Diffe...

Cyclic AMP signalling.

Cyclic adenosine 3′,5′-monophosphate (cAMP) was the first identified second messenger. A large number of studies during the past 30 years have elucidated the fundamental role of cAMP in the cellular response to many hormones and neurotransmitters. Although the main components in the cAMP-mediated signalling pathway are well known, recently new important players have been identified, which have ...

Is Independent of Cyclic AMP

Infusion of forskolin, an adenylate cyclase activator, in concentrations (2 ,uM) that do not alter basal prostaglandin (PG) synthesis inhibit synthesis of PG elicited by isoproterenol in rabbit heart. This inhibitory action of forskolin appears to be dependent on cyclicAMP (cAMP). Bolus injection of forskolin (75 nmol), however, was found to stimulate PG synthesis in rabbit heart. The purpose o...